![]() More recently, researchers discovered that mast cells have an important role in wound healing, in the regulation of the immune system and in keeping us healthy. They secrete histamine and lead to the formation of hives and itchy rashes. They are the central cells in immediate allergic reactions to things like peanuts or bee stings. Mast cells, for the last century, have been understood primarily in the context of allergic disease. I’m assuming if you are reading this blog, you understand what POTS is, but the concept of what mast cells do might be more foreign. This is an extremely complicated intersection of two poorly understood illnesses, so there are more questions than answers right now. It is not clear at this time what the relationship between POTS and MCAS is or how common this overlap is. There seems to be a growing awareness in the medical and patient community that some patients with postural orthostatic tachycardia syndrome (POTS) also have mast cell activation syndrome (MCAS).
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